These antigen-specific factors are synthesized in monocytes and stored in the cytoplasm or on the cell membrane. Transfer factor preparations contain more than 200 different moieties of polypeptide molecules with a molecular weight of <10,000 daltons each moiety potentially has a great number of epitope variations. (5 8) They bridge the generational gap by passing CMI from mother to infant. Transfer factors are components of colostrum, an infant's first meal. Transfer factors promote wellness via CMI. (7) At the time, antibodies were the focus of immune research and little was known of the importance of DTH and of the involvement of T-cells in immune response. (6) In a subsequent study in 1955, Lawrence demonstrated that DTH could be passed serially, first from a positive individual to a negative individual, who became positive, then six months later from the second individual to another negative individual who then became positive. Transfer factors could transfer DTH of a specific form from a skin test positive individual to a skin test negative individual who, after the transfer, would test positive for that antigen. Sherwood Lawrence when he demonstrated that CMI could be transferred from one individual to another by way of low molecular weight extracts of white blood cells. Transfer factors were first discovered in 1949 by Dr. (4 5) Transfer factors obtained from the spray-dried filtrate of bovine colostrum are of two classes: the transfer factors present in the ultra-filtrate of ≤10,000 daltons and other compounds present in the nanofiltrate are ≤3,500 daltons. (1) 4Life's transfer factors are sourced from the ultrafiltration of colostrum and from chicken egg yolks. Transfer factors that have a molecular weight of less than 3,500 daltons modulate immune response, but they do not transfer delayed-type hypersensitivity (DTH). From a molecular biological standpoint, these two properties are analogous to antibodies however, transfer factors' functions of CMI differ almost completely from the functions of antibodies. (1 2) Transfer factors are polypeptides that consist of 40 to 44 amino acids (3) and are thought to have a conserved region and a variable region. Mammalian transfer factors, including those of humans, are small molecules between 3,500 and 10,000 daltons. Transfer factors, which carry antigen-specific information, are produced by mononuclear cells and serve to support and improve immune-mediated pathways (1 2). They support immune function through cell-mediated immunity (CMI). Transfer factors are proteins and peptides that communicate antigenic immunological information intercellularly between a donor and a recipient.
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